Views on the uses of comprehensive two-dimensional gas chromatography-mass spectrometry in food analysis over the literature period 2018–2023

The present manuscript contains critical and constructive views on the uses of comprehensive two-dimensional gas chromatography-mass spectrometry (GC × GC-MS) within the context of food analysis. Focus is devoted to the GC × GC-MS literature covering the period 2018–2023 (nearly 170 articles), even though the conclusions made can be applied, to some extent, to general ones. In fact, even though the use of GC × GC in food analysis has a publication history of just over two decades, it has never gained a firm hold in this field of application, in neither the industry nor in academia. Possible reasons for this lack, along with analytical challenges for which specific GC × GC-MS configurations would certainly be useful, are herein given.