BARRECA Davide

Dr. Davide Barreca is an full professor of biochemistry of the University of Messina. He earned his degree thesis in the laboratory of the Department of Organic and Biological Chemistry, University of Messina, Italy. He graduated on 24/07/03 with laude, arguing the thesis “Effetto di vari additivi sulle proprietà chimico-fisiche dell’Ornitina Carbamiltransferasi”. His thesis topic was on heat stabilization of Ornithine carbamoyltransferase by some additives. He received his doctoral training at the University of Messina, from 2003/04 to 2005/2006 academic years in the Department of Organic and Biological Chemistry, being PhD in “Scienze e Tecniche Molecolari e Cellulari Avanzate per la Diagnostica Clinica ed Epidemiologica”. Dr. Barreca doctoral thesis topic was on the antioxidant and pro-oxidant activity of some poliphenols of natural source on cells culture. During academic years 2005/2006 and 2006/2007, Dr. Barreca has been tutor of Biological Chemistry, Applied Biochemistry and Biochemistry Methodology at the University of Messina, for Degree Course in Biological Science. Since academic years 2008/2009 he is “Cultore della materia” for the teaching of Biochemistry at the University of Messina, for Degree Course in Biological Science. Since 06/06/2008 he attends his post-doctoral training in “Scienze e Tecniche Molecolari e Cellulari” at the University of Messina.
In April 2011, he won a competition for a position of University Researcher in the field BIO/10 (Biochemistry and Clinical Biochemistry), at the Faculty of Pharmacy, University of Messina.
Starting from June 2019, he is associate professor of Biochemistry, at the Faculty of Pharmacy, University of Messina.
Starting from June 2022, he is full professor of Biochemistry, at the Faculty of Pharmacy, University of Messina.
Dr. Barreca is official teacher of the following courses:
- Biochemistry and applied biochemistry for the degree course in Pharmacy
- Biochemical Techniques for the degree course of Biological Sciences
- Biochemistry and applied biochemistry for the degree course in Chemistry and Pharmaceutical Technology
- Biochemistry with elements of clinical biochemistry for the degree course in Pharmaceutical Science applied to Health Products (SFA-PS)
Dr. Barreca research activity has been carried out on diversified topics on:
- biomolecules stabilization processes by sugar, salts, ions and biopolimers through chromatographic, spectroscopic and electrophoresis technique, analyzing chemical-physic variation of solvent and macromolecular solution.
─ purification and characterization of protein in particular on ornithine carbamoyltransferase, isolated from different organism and folding/unfolding studies of the same enzyme
─ biochemistry and physiology adaptation of arginine pathway in marine organism (with particular regard to elasmobranches)
─ pollution monitoring by heavy metal, analyzing biochemistry and physiology modification due to growh in its presence
─ valuation of main pathway involved in subject working in environment with high biological and chemical hazard by enzyme isomorphism profile (lactic and malic dehydrogenase, seperoxide dismutase, caspase, glutamic oxalacetic transaminase) membrane properties and function, primary and secondary metabolites
─ isolation and identification of some poliphenols of natural source and antioxidant and pro-oxidant activity determination by cell culture (HEP, HEP G2, VERO, erythrocyte e lymphocyte) assay
─ studies on erythrocyte membrane, hemolysis assay, lipid peroxidation and membrane fluidity, focusing on Band 3 protein anionic exchange and hemoglobin
─ dynamic and structural correlations between proteins and solvent, in the absence or in the presence of kosmotropes and chaotropes, following folding or unfolding, dehydration and preservation, with the purpose to clarify the relationship functionality/structure
─ protein’s thermodynamic and kinematic parameters (enthalpy, entropy, DG of folding/unfolding, Wyman equation) determination in absence or presence of physical or chemical stresses.
The research activity has been performed using several enzymatic, chromatographic, electrophoresis and spectroscopic techniques, such as HPLC, Circular Dichroism, UGGE (Urea Gradient Gel Electrophoresis), Fluorescence, IR and UV-Visible spectroscopy, Small Angle Neutron Scattering (SANS), HPLC-DAD-MS-MS.
He is a member Italian Society of Neuton Scattering,American Chemical Society, CoNISMa (Consorzio Nazionale Interuniversitario per le Scienze del Mare), International Consortium of Enzyme Inhibitors Research (ICEIR), in the Editorial Board of the journal Eastern-European Journal of Enterprise Technologies, Current Enzyme Inhibition, Phytomedicine, Plants, Frontiers in Pharmacology, Current Molecular Pharmacology, Mini-Reviews In Medicinal Chemistry, Current Cancer Drug Targets, International Journal of Molecular Sciences and Editor in Chief of “Mini-Reviews In Medicinal Chemistry”, Editor of“Clinical Trials and Case Studies”, Academic editor of “Journal of Chemistry”, “PeerJ” e “Genetic Research”, Guest Editor of Current Medicinal Chemistry, Plants and International Journal of Molecular Sciences, in theAdvisory Board of the scientific society "International Natural Product Sciences Taskforce" (INPST, https://inpst.net/), “International summits on Agricultural Biotechnology" and “International Conference on Food & Food Technology” (https://www.aemconferences.com/biotech2019; https://aemconferences.com/food/, 16-17 August 2019 in Dubai, UAE), Organizing Committee Member of “Global Congress and Expo on Biochemistry and Molecular Biology” (https://scientificfederation.com/biomolecular-biology-2020/index.php, March 26-27, 2020 in Krakow, Poland), Program Committee Member of “World Congress on Stem Cells and Regenerative Medicine” (http://stemcells.conferenceera.com/, WCSCRM-2019, October 14-15, 2019, Paris, France), Scientific Committee Member of 4th International Conference on Food and Biosystems Engineering (I.C. FaBE) 30 May-2 June 2019, Crete Island (https://fabe.gr/el/conferences/4th-fabe2019/committees) and1st International Electronic Conference on Plant Science (https://iecps2020.sciforum.net/ online from 01/12/2020 -15/12/2020). Moreover he is peer reviewer for: Food Chemistry, Food Research International, Journal of Agricultural and Food Chemistry, Journal of Food Biochemistry, Molecules, Biological Chemistry, ACS book series, Journal of Chemistry, Food Science and Technology, Chemical Physics, Encyclopedia EOLSS, Cellular & Molecular Biology Letters, Journal of Pharmaceutical and Biomedical Analysis, Environmental Toxicology and Pharmacology, The Journal of Physical Chemistry, Biochimie, Redox Report, Trends in Food Science & Technology, Current Pharmaceutical Biotechnology, International Journal of Biological Macromolecules, Arabian Journal of Chemistry, Evidence-Based Complementary and Alternative Medicine, Journal of Herbal Medicine, Polymer Testing, Proteome Science, Phytotherapy research, Phytochemistry Letters, Planta, Analytical Methods, Current Pharmaceucal Biotechnology, Bioorganic & Medicinal Chemistry Letters, Current Neuropharmacology, Vibrational Spectroscopy, Antonie van Leeuwenhoek Journal of Microbiology, Chemico-Biological Interactions, Mediators of Inflammation, Biomedicine, Antioxidant, Phytochemistry, Industrial Crops and Products, Mutagenesis, Molecular Nutrition and Food Research, Trends in Analytical Chemistry, Critical Reviews in Biotechnology, Plant Physiology and Biochemistry, Journal of Biochemical and Molecular Toxicology, BBA-Biomembranes, Biofactors, Phytomedicine, Oxidative Medicine and Cellular Longevity, BBA - Molecular Cell Research, Biotechnology Advance e Seminars in Cancer Biology.
The research activity is attested by publications on international journals and participation to national and international conferences.