Re-thinking organic synthesis: Mechanochemistry as a greener approach

The increasing advances in mechanochemistry have opened new possibilities to develop organic processes in a more sustainable way. In this contribution, recent progress in this area has been described, going from laboratory scale protocols to industrial applications. Moreover, innovations in mechanochemical procedures and in-situ characterization analyses have been also discussed. Envisioning scale-up applications, several technologies such as twin-screw extrusion and high-throughput reaction platforms, able to combine continuous-flow mechanochemical and thermal conditions, have been investigated and developed. It is worth remarking that mechanochemistry is a highly promising approach with a lot of potentialities still to be unraveled.