On the performance of laser-synthesized, SERS-based sensors for drug detection

We have tested thin nano roughened Au films produced by pulsed laser deposition for quantitative SERS sensing of the anti-epileptic drug Perampanel within the range of concentrations of therapeutic interest (3 × 10−7 M–3 × 10−6 M). We propose a model to elucidate the dependence of the SERS intensity as a function of analyte concentration and contact time between the Au surface and the solution. © 2019 Elsevier B.V.