Therapeutic efficacy of palmitoylethanolamide and its new formulations in synergy with different antioxidant molecules present in diets

The use of a complete nutritional approach seems increasingly promising to combat chronic
inflammation. The choice of healthy sources of carbohydrates, fats, and proteins, associated with
regular physical activity and avoidance of smoking is essential to fight the war against chronic
diseases. At the base of the analgesic, anti-inflammatory, or antioxidant action of the diets, there
are numerous molecules, among which some of a lipidic nature very active in the inflammatory
pathway. One class of molecules found in diets with anti-inflammatory actions are ALIAmides.
Among all, one is particularly known for its ability to counteract the inflammatory cascade, the
Palmitoylethanolamide (PEA). PEA is a molecular that is present in nature, in numerous foods, and is
endogenously produced by our body, which acts as a balancer of inflammatory processes, also known
as endocannabionoid-like. PEA is often used in the treatment of both acute and chronic inflammatory
pathologies, either alone or in association with other molecules with properties, such as antioxidants
or analgesics. This review aims to illustrate an overview of the different diets that are involved in the
process of opposition to the inflammatory cascade, focusing on capacity of PEA and new formulations
in synergy with other molecules