Revised north star ambulatory assessment for young boys with Duchenne muscular dystrophy

Articolo

Data di Pubblicazione:

2016

Abstract:

TheadventoftherapeuticapproachesforDuchennemusculardystrophy(DMD)has highlightedtheneedtoidentifyreliableoutcomemeasuresforyoungboyswithDMD.The aimofthisstudywastodeveloparevisedversion oftheNorth StarAmbulatoryAssessment (NSAA)suitableforboysbetweentheageof3and5yearsbyidentifying ageappropriate itemsandrevisingthescoringsystemaccordingly.Usingthescalein171controlsbetween theageof2.9and4.8years,weidentifieditemsthatwereappropriateatdifferent age points.Anitemwasdefinedasageappropriateifitwascompleted,achievingafullscore, byatleast85%ofthetypicallydevelopingboysatthatage.At3years(±3months)there wereonly8itemsthatwereageappropriate,at3yearsand6monthstherewere13items whilebytheageof4yearsall17itemswereappropriate.Arevisedversionofthescalewas developedwithitemsorderedaccordingtotheagewhentheycouldbereliablyperformed. TheapplicationoftherevisedversionofthescaletodatacollectedinyoungDMDboys showedthatveryfewoftheDMDboyswereabletocompletewithafullscorealltheage appropriateitems.Inconclusion,ourstudysuggeststhatarevisedversionoftheNSAAcan beusedinboysfromtheageof3yearstoobtaininformationonhowyoungDMDboys acquirenewabilitiesandhowthiscorrelateswiththeirpeers.

Tipologia CRIS:

14.a.1 Articolo su rivista

Keywords:

Medicine (all); Biochemistry, Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)

Elenco autori: