Self-assembly of amphiphilic anionic calix[4]arenes and encapsulation of poorly soluble naproxen and flurbiprofen
Academic Article
Publication Date:
2015
abstract:
Supramolecular aggregates formed through the association of an amphiphilic tetra-O-butylsulfonate calix[4]arene 1 were investigated in aqueous solution by a combination of different techniques (NMR, DLS and AFM). The ability of the micellar aggregates of calixarene 1 to increase the solubility of poorly water-soluble drugs was studied.
Iris type:
14.a.1 Articolo su rivista
Keywords:
calixarenes, micelles, dosy, naproxen, flurbiprofen, DISSOCIATION-CONSTANTS, WATER; DRUG, RECOGNITION, MICELLES, SOLUBILIZATION, AGGREGATION, AMINES
List of contributors:
BARBERA, LUCIA; GATTUSO, Giuseppe; KOHNKE, Franz Heinrich; NOTTI, Anna; Pappalardo, Sebastiano; PARISI, Melchiorre; PISAGATTI, Ilenia; PATANE', Salvatore; Micali, Norberto; Villari, Valentina
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