[Immunomodulating action of prostaglandins].

The effect of 16,16-dimethyl-PGE2-methyl ester (di-M-PGE2) on humoral and cellular immunoresponsiveness has been compared in normal mice and in mice immunosuppressed by thymectomy plus antitymocyte serum. Di-M-PGE2 augmented the humoral and cellular immunoresponse in in mice immunosuppressed by thymectomy plus antithymocyte serum. Thiis was manifested by slowing of the growth of B-16 melanoma and by stimulating the of plaque-forming cells, heagglutinin titers, and delayed hypersensitivity reactions to sheep erytrocytes. In contrast, in normal (non-immunosuppressed) mice, di-M-PGE2 was mildly immunosuppressive.