Endoscopic resection as a safe and effective technique for treatment of pedunculated and non-pedunculated benign-appearing colorectal neoplasms measuring 40 mm or more in size

Aim The aim of this paper was to evaluate the outcome of endoscopic resection (ER) for pedunculated and non-pedunculated colorectal neoplasms exceeding 4 cm in size Methods All patients with a colorectal neoplasms measuring 4 cm or more, who underwent ER at our institution between January 1996 and December 2008 were included in the study Results In the study period, 67 ERs were carried out in 67 patients with a mean (+/- SD) age of 72 +/- 11 years The mean neoplasms size was 48 2 +/- 12 5 mm There were 32 sessile, 26 flat and 9 pedunculated neoplasms The most frequent location (49 3%) was rectum No perforation occurred, there were 4 procedural and 2 delayed bleeding, treated endoscopically, and 3 cases of transmural burn syndrome, managed conservatively Pathologic examination showed 18 low-grade dysplasia, 43 high-grade dysplasia, 3 intramucosal and 3 invasive cancer The most frequent type of neoplasm was villous adenoma (76 1%) The presence of malignancy was related to villous histology (P=0 005) and to age >= 80 of patients (P=0 04) Results During endoscopic follow up (49 4 26 3 months) recurrence was found in 25 8% of lesions (11 sessile and 4 flat), always treated endoscopically Recurrence was more likely in patients with lesions larger than 60 mm (P=0 04) The three patients with invasive cancer did not undergo surgery, because of advanced age and/or severe extracolonic diseases During follow-up no local recurrence or metastasis was found Conclusion ER is a safe and effective procedure for removing benign appearing very large colorectal neoplasms