Molecular apparatus for Automatic Titrations

A composite kinetic molecular device formed by a molecular titrator ([1.1.1]cryptand (A)) and a molecular pH meter (bromothymol blue (B)) was used as a substitute for the usual physical apparatus to perform an automatic spectrophotometric determination of the pKa of nimesulide (C). The confinement of the whole apparatus inside the spectrophotometric cuvette makes high-throughput pKa and stability determination in pharmaceutical analysis possible.