Effect of initial levothyroxine dose on neurodevelopmental and growth outcomes in children with congenital hypothyroidism
Academic Article
Publication Date:
2022
abstract:
We designed a multicentre open prospective randomized trial to evaluate the risk-benefit profile of two different initial treatment schemes with levothyroxine (L-T4), 10-12.5 μg/kg/day vs 12.6-15 μg/kg/day, on growth and neurodevelopmental outcomes in children with congenital hypothyroidism (CH) detected by neonatal screening to identify the best range dose to achieve optimal neurocognitive development.
Iris type:
14.a.1 Articolo su rivista
Keywords:
congenital hypothyroidism; growth; levothyroxine treatment; neonatal screening; neurocognitive; Child; Child, Preschool; Humans; Infant, Newborn; Prospective Studies; Thyroid Hormones; Thyrotropin; Congenital Hypothyroidism; Thyroxine
List of contributors:
Esposito, Andrea; Vigone, Maria Cristina; Polizzi, Miriam; Wasniewska, Malgorzata Gabriela; Cassio, Alessandra; Mussa, Alessandro; Gastaldi, Roberto; Di Mase, Raffaella; Vincenzi, Gaia; Pozzi, Clara; Peroni, Elena; Bravaccio, Carmela; Capalbo, Donatella; Bruzzese, Dario; Salerno, Mariacarolina
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