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Surgical De-Escalation for Re-Excision in Patients with a Margin Less Than 2 mm and a Diagnosis of DCIS

Articolo
Data di Pubblicazione:
2024
Abstract:
The current surgical guidelines recommend an optimal margin width of 2 mm for the management of patients diagnosed with ductal carcinoma in situ (DCIS). However, there are still many controversies regarding re-excision when the optimal margin criteria are not met in the first resection. The purpose of this study is to understand the importance of surgical margin width, re-excision, and treatments to avoid additional surgery on locoregional recurrence (LRR). The study is retrospective and analyzed surgical margins, adjuvant treatments, re-excision, and LRR in patients with DCIS who underwent breast-conserving surgery (BCS). A total of 197 patients were enrolled. Re-operation for a close margin rate was 13.5%, and the 3-year recurrence was 7.6%. No difference in the LRR was reported among the patients subjected to BCS regardless of the margin width (p = 0.295). The recurrence rate according to margin status was not significant (p = 0.484). Approximately 36.9% (n: 79) patients had resection margins < 2 mm. A sub-analysis of patients with margins < 2 mm showed no difference in the recurrence between the patients treated with a second surgery and those treated with radiation (p = 0.091). The recurrence rate according to margin status in patients with margins < 2 mm was not significant (p = 0.161). The margin was not a predictive factor of LRR p = 0.999. Surgical re-excision should be avoided in patients with a focally positive margin and no evidence of the disease at post-surgical imaging.
Tipologia CRIS:
14.a.1 Articolo su rivista
Keywords:
DCIS; ductal carcinoma in situ; locoregional recurrence; omitting margin re-excision; surgical de-escalation
Elenco autori:
Vanni, Gianluca; Pellicciaro, Marco; Di Lorenzo, Nicola; Barbarino, Rosaria; Materazzo, Marco; Tacconi, Federico; Squeri, Andrea; D’Angelillo, Rolando Maria; Berretta, Massimiliano; Buonomo, Oreste Claudio
Autori di Ateneo:
BERRETTA Massimiliano
Link alla scheda completa:
https://iris.unime.it/handle/11570/3296145
Pubblicato in:
CANCERS
Journal
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