Molecular characterization of a peculiar blood clot fluidification by theoretical thermodynamic models and entropy production study.

In this paper we analyzed thermodynamic functions of blood clot perturbed with a harmonic mechanical waves in the context of the non equilibriumthermodynamic. At a frequency N650 Hz, the clot shows a trend of increasing entropy that confirm what discussed in our previous paper. In details, blood clot seems to tend towards a fluidification process. We hypothesize that the impact of the wave on the blood can trigger a cooperative event of breaking the bonds present inside the clot. This means that a “refractory” state or a threshold is exceeded, beyond which the fluidization starts, probably triggered by the activation of the enzymes. The event is further favored by the intervention of the water molecules that hydrolyze the ATP released by the red blood cells.