A thermodynamic characterization of the phenomena evolving in cancer pathology by dielectric relaxation in blood: A new approach by construction of TTM (Thermodynamic Tumor Matrix)

The paper shows a thermodynamic characterization of the phenomena evolving in cancer pathology on the blood. The goal of the study is cancer characterization at stages that cannot be identified by oncologists. In this context, the non-equilibrium thermodynamic approach is exploited to calculate the thermodynamic functions deriving by the complex dielectric constant related to blood measurements after stimulation with a harmonic electric field. Calculated functions allowthe construction of a matrix, indicated as Thermodynamic TumorMatrix (TTM) that, gives detailed and selective information. This procedure allowed to highlight blood changes associated with a decrease in orientation polarization P(1) over time. P(1) attenuation may be explained by the intravasation phenomenon. In this context, negative charged cancer cells polarizing under the effect of the harmonic electric field, generate an opposing field E(1) responsible of the P(1) attenuation in intensity. This hypothesis is confirmed by the measurement of the displacement currents.