Data di Pubblicazione:
2004
Abstract:
Background
The use of aspirin for the prevention of thrombotic complications in polycythemia vera
is controversial.
Methods
We enrolled 518 patients with polycythemia vera, no clear indication for aspirin treat-
ment, and no contraindication to such treatment in a double-blind, placebo-controlled,
randomized trial to assess the safety and efficacy of prophylaxis with low-dose aspirin
(100 mg daily). The two primary end points were the cumulative rate of nonfatal myo-
cardial infarction, nonfatal stroke, or death from cardiovascular causes and the cumu-
lative rate of nonfatal myocardial infarction, nonfatal stroke, pulmonary embolism,
major venous thrombosis, or death from cardiovascular causes. The mean duration of
follow-up was about three years.
Results
Treatment with aspirin, as compared with placebo, reduced the risk of the combined
end point of nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascu-
lar causes (relative risk, 0.41; 95 percent confidence interval, 0.15 to 1.15; P=0.09) and
the risk of the combined end point of nonfatal myocardial infarction, nonfatal stroke,
pulmonary embolism, major venous thrombosis, or death from cardiovascular causes
(relative risk, 0.40; 95 percent confidence interval, 0.18 to 0.91; P=0.03). Overall mor-
tality and cardiovascular mortality were not reduced significantly. The incidence of ma-
jor bleeding episodes was not significantly increased in the aspirin group (relative risk,
1.62; 95 percent confidence interval, 0.27 to 9.71).
Conclusions
Low-dose aspirin can safely prevent thrombotic complications in patients with poly-
cythemia vera who have no contraindications to such treatment.
Tipologia CRIS:
14.a.1 Articolo su rivista
Elenco autori:
Landolfi, R; Marchioli, R; Kutti, J; Gisslinger, H; Tognoni, G; Patrono, C; Barbui, T; Landolfi, R; Marchioli, R; Kutti, J; Gisslinger, H; Tognoni, G; Patrono, C; Barbui, T; Gisslinger, H; Barbui, T; Finazzi, G; Pusterla, S; Falanga, A; Galli, M; Kutti, J; Wadenvik, H; Gastl, G; Ludescher, C; Lutz, D; Girschikofsky, M; Michlmayr, G; Rechberger, E; Niessner, H; Ivansich, E; Rain, Jd; Chommienne Thomas, C; Hehlmann, R; Engelich, G; Kohne, E; Kramer, A; Christakis, Ji; Papaioannou, M; Gerotziafas, G; O'Donnell, R; Bennett, M; Lugassy, G; Ellis, M; Eldor, A; Naparstek, E; Marilus, R; Leoni, P; Rupoli, S; Scortechini, Ar; Agostini, V; Volpe, E; Calmieri, F; Volpe, A; Storti, G; Ciampa, A; Dammacco, F; Lauta, Vm; Ranieri, G; Rizzi, R; Orsola, S; Tura, S; Finelli, C; Marino, G; Rossi, G; Almici, C; Capucci, A; Zanetti, F; Giustolisi, R; Cacciola, Rr; Cacciola, E; Peta, A; Magro, D; Frigerio, G; Alberio, F; Beretta, A; Bonferroni, M; Raviolo, A; Ferrini, Prl; Grossi, A; Fabbri, A; Nardelli, S; Centra, A; Musolino, C; Bellomo, G; Trincali, O; Spatari, Giovanna; Foa, P; Gerli, G; Carraro, Mc; Zanella, A; Lurlo, A; Barraco, F; Torelli, G; Marietta, M; Pogliani, E; Miccolis, Ir; La Rocca, A; Puglisi, A; Sardeo, G; Rotoli, B; Martinelli, V; Ciancia, R; Cardarelli, A; Cimino, R; Fasanaro, A; Randi, Ml; Rizzoli, V; Caramatti, C; Gaeta, L; Lazzarino, M; Passamonti, F; Lazzola, M; Malabarba, L; Natale, D; Pulini, S; Davi, G; Gugliotta, L; Ilariucci, F; Landolfi, R; De Candia, E; Eugenio, S; Amadori, S; Buccisano, F; Mandelli, F; Montefusco, E; Petti, Mc; Spadea, A; Carotenuto, M; Morelli, A; Nobile, M; Longinotti, M; Pardini, Sm; Lauria, F; Buccalossi, A; Gentili, S; Mazza, P; Cervellera, M; Maggi, A; Di Francesco, A; Pasqualoni, E; Chisesi, T; Polacco, A; Chisesi, T; Capnist, G; Rodeghiero, F; Ruggeri, M; Arrizabalaga, B; Remacha, A; De Mendiguren, Bp; Hernandez Nieto, L; Hernandez Garcia, Mt; Gonzalez Brito, G; Machado, P; Garcia, G; Villegas, A; Pena, A; Fernandez, Ag; Carbonell, F; Del Arco, A; Back, H; Stenke, L; Hansen, S; Larsson, G; Stromblad, G; Lauri, B; Ryden, Bo; Linder, O; Lundholm, Bg; Lannemyr, O; Strandberg, M; Andreasson, B; Stockelberg, D; Pasquariello, F; Tichelli, A; Otremba, B; Hinrichs, Hf; Weber Stadelmann, W; Bareford, D; Oscier, Dg; Bowey, N; Taylor, Pc; Landolfi, R; Barbui, T; de Gaetano, G; Marchioli, R; Najean, Y; Patrono, C; Pearson, Tc; Marchioli, R; Di Blasio, A; Atashkar, S; Finazzi, G; Gisslinger, H; Mari, E; Tamayo, D; Tognoni, G; Borelli, G; Ferri, B; Marfisi, Rm; Olivieri, M; Polidoro, A; Spoltore, R; Landolfi, R; Levantesi, G; Di Mascio, R; Finazzi, G; Miceli, G; Sperti, G; Correale, E; Vermjlen, J; Collins, R.
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