Clinical efficacy of two different drug combinations for the treatment of canine leishmaniasis
Articolo
Data di Pubblicazione:
2008
Abstract:
SUMMARY - In a not blind field controlled trial the clinical efficacy and safety of meglumine
antimoniate (Glucantime®), combined with allopurinol (Zyloric®) or spiramycin &
metronidazole (Stomorgyl®), were evaluated in dogs with leishmaniasis. In all, 4 different
treatment groups were compared: Glucantime® for 1 month and Stomorgyl® (6 dogs) or
Zyloric® (9 dogs) for 90 days; Glucantime® for 2 months and Stomorgyl® (8 dogs) or
Zyloric® (6 dogs) for 90 days. The clinical picture was scored using a numerical rate of the
severity of clinical signs and changes in CBC, biochemical profile, albumin, globulins,
proteinuria, IFAT titre. The 2 month course of antimony therapy produced better results than the
1 month course and the Stomorgyl® combination was better than the allopurinol combination.
antimoniate (Glucantime®), combined with allopurinol (Zyloric®) or spiramycin &
metronidazole (Stomorgyl®), were evaluated in dogs with leishmaniasis. In all, 4 different
treatment groups were compared: Glucantime® for 1 month and Stomorgyl® (6 dogs) or
Zyloric® (9 dogs) for 90 days; Glucantime® for 2 months and Stomorgyl® (8 dogs) or
Zyloric® (6 dogs) for 90 days. The clinical picture was scored using a numerical rate of the
severity of clinical signs and changes in CBC, biochemical profile, albumin, globulins,
proteinuria, IFAT titre. The 2 month course of antimony therapy produced better results than the
1 month course and the Stomorgyl® combination was better than the allopurinol combination.
Tipologia CRIS:
14.a.2 Proceedings in extenso su rivista
Keywords:
Allopurinol; Dog; Leishmaniasis; Meglumine antimoniate; Metronidazole; Spiramycin; Therapy
Elenco autori:
Pennisi, Maria Grazia; LO GIUDICE, S; Masucci, Marisa; DE MAJO, Massimo; Reale, S; Vitale, F.
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